Glutathione (GSH) is a naturally occurring compound that plays a crucial role in cellular responses to oxidative stress through its ability to scavenge free radicals, thereby mitigating the risk of potential damage, including cell death. . Alterations in glutathione homeostasis could be used as potential markers of human disease. In situations where endogenous glutathione is depleted, exogenous glutathione can be used to replenish it.
There are two types of glutathione powder, both of which can be converted into each other:
Reduced Glutathione (GSH): This is the active form of the antioxidant.
Oxidized glutathione (GSSG): This is the inactive form of glutathione.
Under physiological conditions, most are only in reduced form. It acts on free radicals in the cellular environment and is oxidized and becomes inactive, thereby transforming into GSSG. The good part is that it can be converted back to its active form by the glutathione reductase enzyme present in our bodies.
Whitening and anti-aging
Glutathione is found in large amounts in all cells of the body and is a powerful antioxidant.
GSHWORLD Glutathione helps protect us from the harmful effects of oxidative stress, which is linked to many skin problems such as acne, rosacea, psoriasis, eczema, age spots, blemishes, sun spots, redness, inflammation, wrinkles, Fine lines and more.
- Anti-melanogenic properties: Glutathione stimulates the synthesis of pheomelanin, rather than dark melanin. Ppheomelanin is lighter in color (yellow-red), so an increased proportion of pheomelanin is associated with lighter skin color. It interferes with the transport of melanogenic enzymes, inhibits tyrosinase activity, and melanosome transfer in multiple ways. One study showed that glutathione was superior to 2% hydroquinone in reducing skin melanin index.
- Antioxidant Properties: Glutathione scavenges free radicals that damage the skin when exposed to UV rays or any other environmental damage. These free radicals may induce melanogenesis (the formation of melanin) and cause tissue damage, leading to wrinkles, inflammation, and more.
- Anti-aging properties: It increases collagen stimulation, thereby reducing the formation of wrinkles, and also helps improve the skin’s moisture content.
Formulations and Synergies
Glutathione comes in the form of serums, lotions, cleansers, and topical creams. It is available as regular tablets, effervescent tablets, oral spray and oral syrup.
01 Oral doses of glutathione can be combined with ascorbic acid, lipoic acid, N-acetylcysteine, and grape seed extract:
★Vitamin C helps maintain glutathione in its active form and improves its oral bioavailability.
★Lipoic acid and glutathione work synergistically as antioxidants to increase glutathione levels in the blood and cells.
★N-Acetyl Cysteine enhances its anti-aging effects.
★Grape seed extract adds antioxidant benefits to the skin.
02 Topically applied glutathione can supplement:
★Ascorbic acid (vitamin C) enhances the antioxidant effect of glutathione.
★Kojic acid can lighten skin pigmentation.
★Tranexamic acid reduces pigmentation production by reducing melanin, so it has a synergistic effect with glutathione.
03 Avoid using the following ingredients with topical glutathione:
★Concomitant use of retinol/retinaldehyde may counteract the effects of glutathione
★AHA/BHA may affect the stability of reduced glutathione and harm the skin.
★Anti-acne ingredients may cause irritation and disrupt skin’s pH.
Necessary supplementary glutathione
Glutathione continues to attract extensive research attention due to its critical role in nearly all plant and animal species.
Glutathione plays a central role as an antioxidant against ROS, thus regulating signaling pathways involved in cellular homeostasis. Glutathione also plays important roles in different cellular processes, including proliferation, apoptosis, immune system regulation, and cell component metabolism. The functional outcome of glutathione is regulated by the ratio between its reduced (GSH) and oxidized forms (GSSG), which is indicative of the level of oxidative stress.
While endogenous glutathione (containing higher concentrations of glutathione) optimally regulates cellular homeostasis, exogenous glutathione is necessary in situations where ROS production is upregulated.
Glutathione is also a participant in cell metabolism. The side effects of oral supplementation are mild, similar to the usual intake of high-dose vitamin supplements. But glutathione is still not recommended for pregnant women and people under 18 years of age. Mild erythema may also occur in rare cases when applied topically.
GSHWORLD provides high-quality reduced glutathione (GSH), acetyl glutathione (SAG) and oxidized glutathione (GSSG) raw materials. The products are exported to Europe, America, South Korea, India and other parts of the world. If you are interested in Interested in GSHWORLD products, please feel free to contact Glutathione supplier, we will be happy to provide any information you need.